Nicergoline (pronounced nice-er-go-lean) is perhaps the latest commercially available variation of all the ergot preparations. It has become most popular in Japan and indeed many of its clinical trials have been performed there. Nicergoline appears to be a potent vasodilator (improving brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. However, clinical trials confirm that nicergoline also improves blood circulation in the lungs and limbs and that blood platelet aggregation is inhibited. Studies also indicate that nicergoline does not affect arterial tension and that in cases of patients suffering from hypertension, it may induce a gradual lowering of the tension. The mechanism of Nicergoline is to increase vascular circulation in the brain and by enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter. According to the Manufacturer's insert, Sermion (nicergoline) has proved to be effective in hospital use, regulating and improving brain disorders caused by metabolic-vascular insufficiency and alterations derived from insufficient arterial irrigation in the limbs. Do not take if you are pregnant or breast-feeding. May cause gastro-intestinal disturbances and hypotension. One study shows that Nicergoline enhances the cardiac depressant action of Propranolol.
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